A Comparative Study between Intramuscular Midazolam and Oral Clonidine as a Premedication for General Anesthesia

Background: Most anesthesiologists agree on the need for efficient pre-medication. The pattern of desired effects of a pre-medication is however, complex and includes relief of anxiety, sedation and relaxation of the patient. The present study was undertaken to compare the effects of Midazolam and clonidine as premedication. Methodology: A comparative study between midazolam and clonidine as a premedication for general anesthesia was conducted. Patients were divided in two groups: Group I: Inj. Midazolam 0.07 mg/kg i.m. before surgery; Group II Tab.Clonidine 4μg/kg oral, 2 hours before surgery. Pulse rate, blood pressure, state of excitement, apprehension and sedation were noted at the time of giving premedication. Results: Majority of cases in both the groups were in the age group of 16-30 years (56%). Gender wise distribution shows 40% cases were males and 60% were females. The sedation score, apprehension score and excitement score in both the groups before and after induction was statistically significant. There is no significant difference in dose requirement of pentothal for induction between midazolam and clonidine group. The amnesia score shows that midazolam produces more potent and perfect amnesia as compared to clonidine. Amnesia score in both the groups was statistically significant Conclusion: It was concluded from the present study that midazolam was superior to clonidine in its sedative and anxiolytic effects, had a potent amnesia and does not attenuate hemodynamic response to laryngoscopy and intubation and does not prolong recovery time.